Wild guess, but… v5 introduced some use of extended sqlite syntax for DataConnector database management. From the error text it looks like your SQLite version is older than one that’s expected to be shipped with Easymorph and one that doesn’t support this syntax.
It could happen if an earlier version of System.Data.Sqlite.* (specifically, it’s sqlite pre-3.24.0, that corresponds to 22.214.171.124 version of System.Data.Sqlite) is installed in your GAC (with version redirect policy, perhaps).
Could you maybe try a clean install (on another PC or Windows Sandbox / Virtual machine) to see if problem persists?